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KMID : 0388720210280020055
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Journal of Korean Society of Spine Surgery
2021 Volume.28 No. 2 p.55 ~ p.62
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Treatment for Gorham-Stout Disease Involving the Spinal Column: A Narrative Review
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Chang Sam-Yeol
Kim Hyoung-Min
Chang Bong-Soon
Lee Choon-Ki
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Abstract
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Study Design: Narrative review.
Objectives: To present up-to-date evidence on the treatment of Gorham-Stout disease (GSD) involving the spinal column.
Summary of Literature Review: Gorham-Stout disease (GSD) is a rare disease that is characterized by progressive bone resorption associated with vascular or lymphatic angiomatosis. Although various treatment options have been described and investigated, there is no consensus on the appropriate treatment for GSD.
Materials and Methods: Review of the associated literature and latest research.
Results: The available treatment options for spinal GSD are systemic agents (including interferon-alpha, bisphosphonate, denosumab, and sirolimus), radiotherapy, surgical treatment, and percutaneous vertebroplasty.
Conclusions: Treatment for spinal GSD should be case-specific and involve multiple modalities, including systemic medications, radiotherapy, and surgical treatment.
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KEYWORD
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Gorham-Stout disease, Denosumab, Sirolimus, Radiotherapy, Vertebroplasty
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